Abstract #2585

Fast 3D Wave-CAIPI Susceptibility Weighted Imaging and SPACE FLAIR for Comprehensive Evaluation of Demyelinating Lesions in Multiple Sclerosis

Augusto Lio M. Goncalves Filho^1,2, Azadeh Tabari^1,2, Chanon Ngamsombat³, Ilena George⁴, Stephen F. Cauley², Wei Liu⁵, Daniel N. Splitthoff⁶, Wei-Ching Lo⁷, Pamela W. Schaefer¹, Otto Rapalino¹, Eric C. Klawiter⁴, John Conklin^1,2, and Susie Y. Huang^1,2

¹Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ²Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ³Department of Radiology, Siriraj Hospital, Bangkok, Thailand, ⁴Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, ⁵Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, ⁶Siemens Healthcare GmbH, Erlangen, Germany, ⁷Siemens Medical Solutions Inc., Boston, MA, United States

The central vein sign (CVS) and paramagnetic rims are imaging signs specific for demyelinating lesions in multiple sclerosis (MS) that can be detected using high-resolution susceptibility-weighted imaging (SWI) and FLAIR sequences. We developed an optimized protocol for fast, comprehensive evaluation of demyelinating lesions including highly accelerated Wave-CAIPI SWI and FLAIR. In 65 patients undergoing evaluation for demyelinating disease, we found that 72% of MS and CIS patients had at least one CVS, and 45% showed at least one paramagnetic rim. The application of highly accelerated Wave-SWI and Wave-FLAIR may improve the characterization of MS lesions in clinically feasible acquisition times.

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