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Abstract #2585

Fast 3D Wave-CAIPI Susceptibility Weighted Imaging and SPACE FLAIR for Comprehensive Evaluation of Demyelinating Lesions in Multiple Sclerosis

Augusto Lio M. Goncalves Filho1,2, Azadeh Tabari1,2, Chanon Ngamsombat3, Ilena George4, Stephen F. Cauley2, Wei Liu5, Daniel N. Splitthoff6, Wei-Ching Lo7, Pamela W. Schaefer1, Otto Rapalino1, Eric C. Klawiter4, John Conklin1,2, and Susie Y. Huang1,2
1Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 2Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Department of Radiology, Siriraj Hospital, Bangkok, Thailand, 4Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 5Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China, 6Siemens Healthcare GmbH, Erlangen, Germany, 7Siemens Medical Solutions Inc., Boston, MA, United States

The central vein sign (CVS) and paramagnetic rims are imaging signs specific for demyelinating lesions in multiple sclerosis (MS) that can be detected using high-resolution susceptibility-weighted imaging (SWI) and FLAIR sequences. We developed an optimized protocol for fast, comprehensive evaluation of demyelinating lesions including highly accelerated Wave-CAIPI SWI and FLAIR. In 65 patients undergoing evaluation for demyelinating disease, we found that 72% of MS and CIS patients had at least one CVS, and 45% showed at least one paramagnetic rim. The application of highly accelerated Wave-SWI and Wave-FLAIR may improve the characterization of MS lesions in clinically feasible acquisition times.

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