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Abstract #2586

Glioblastoma Recurrence vs. Radiotherapy Injury: Combined Model of DKI and 11C-MET Using PET/MR May Increase Accuracy of Differentiation

Haodan Dang1, Ruimin Wang1, Jiajin Liu1, Huaping Fu1, Mu Lin2, Jiahe Tian1, Jinming Zhang1, and Baixuan Xu1
1Department of nuclear medicine, Chinese PLA General Hospital, Beijing, China, 22. MR Collaboration, Diagnostic Imaging, Siemens Healthcare, Shanghai, China

The purpose of this study was to evaluate the diagnostic potential of decision-tree model of diffusion kurtosis imaging (DKI) and 11C-methionine (11C-MET) PET imaging, for the differentiation of radiotherapy injury from glioblastoma recurrence using integrated PET/MR. Eighty-six glioblastoma cases with suspected lesions after radiotherapy were retrospectively enrolled. Compared to models of DKI-alone (AUC=0.85) and PET-alone (AUC=0.89), the combined model demonstrated the best diagnostic accuracy (AUC=0.95). The decision-tree model has the potential to further increase diagnostic accuracy for discrimination between radiotherapy injury and glioblastoma recurrence. 11C-MET PET/MR may thus contribute to the management of glioblastoma patients with suspected lesions after radiotherapy.

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