Abstract #2589

Noninvasive assessment of MGMT promoter methylation status in grade II-IV gliomas using inflow-based vascular-space-occupancy

Yuankui Wu¹, Wenle He^1,2, Wensheng Wang², Jun Hua^3,4, Xiang Xiao¹, Xiaomin Liu¹, Yikai Xu¹, and Yingjie Mei⁵

¹Department of Medical Imaging, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Department of Radiology, Guangdong 999 Brain Hospital, Guangzhou, China, ³Neurosection, Division of MRI Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Philips healthcare, Guangzhou, China

Accurate prediction of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation status preoperatively is important. DSC-MRI can predict MGMT promoter methylation status in glioblastomas but not in lower-grade gliomas. Inflow-based vascular-space-occupancy (iVASO), a novel perfusion technique without the need for exogenous contrast agents, emphasizes the perfusion blood volume in arteries and arterioles. In this study, the predictive ability for MGMT promoter methylation status of iVASO histogram features was investigated. The results showed that iVASO-based histogram features accurately predicted the methylation status of MGMT promoter in gliomas. This suggests that iVASO may be a promising noninvasive imaging tool in predicting MGMT promoter methylation.

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