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Abstract #2590

Susceptibility-Based Characterization of Venous Distribution and Oxygen Extraction Fraction in Brains with Glioma at 7T

Shihui Zhou1,2, Huilou Liang2,3, Yuchao Liang4, Siqi Cai1,2, Chunxiang Jiang1,2, Rong Xue2,3, Lei Wang4, and Lijuan Zhang*1
1Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2University of Chinese Academy of Sciences, Beijing, China, 3State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 4Neurosurgery, Beijing Tiantan Hospital of Capital Medical University, Beijing, China

Vein density and oxygen extraction fraction were quantified in brains with glioma using a susceptibility-based approach at 7T. Brains with low grade glioma featured more extensive areas with significant difference in vein density and OEF between the homotopic ROIs that mainly involve fronto-parietal areas and basal ganglia, in contrast to brains with high grade glioma with the differential vein density and OEF distribution mainly involving bilateral thalami. The inter-homotopic measurements of vein density and OEF were significantly correlated, suggesting that the oxygen metabolism malfunction in brains with high grade glioma might be partially ascribed to the altered venous distribution.

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