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Abstract #2594

Ultra-High Field Sodium MRI in Alzheimer’s Disease Reveals Stage-dependent Metabolic Alterations Associated with Tau-pathology

Alexa Haeger1,2,3, Michel Bottlaender1,4, Julien Lagarde4,5,6, Renata Porciuncula Baptista1, Cécile Rabrait-Lerman1, Volker Luecken2,3, Jörg Bernhard Schulz2,3, Alexandre Vignaud1, Marie Sarazin4,5,6, Kathrin Reetz2,3, Sandro Romanzetti2,3, and Fawzi Boumezbeur1
1BAOBAB, CNRS, Paris-Saclay University, CEA-NeuroSpin, Gif-sur-Yvette, France, 2Department of Neurology, RWTH Aachen University, Aachen, Germany, 3JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH, Julich, Germany, 4BioMaps, CNRS, Inserm, Paris-Saclay University, CEA-SHFJ, Orsay, France, 5Neurology of Memory and Language, GHU Paris Psychiatrie & Neurosciences, Sainte-Anne Hospital, Paris, France, 6Université de Paris, Paris, France

Deficits in brain cells’ homeostasis and metabolism are suspected to occur ahead of the atrophy observed throughout the brain of AD patients with potential interactions between Amyloid/Tau deposits and the Na/K-pump activity leading to increased cerebral sodium concentrations. Yet this increase remains to be confirmed. We present a multimodal imaging study combining structural 1H-MRI, quantitative 23Na MRI at 7T in association with Tau- and Amyloid-PET. We show that total sodium concentration is increased in multiple brain regions in AD compared to cognitively healthy controls, and that these changes are more strongly correlated with local Tau- than Amyloid-loads.

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