Abstract #2595

Feasibility of Arterial Spin Labeling for Detection of Longitudinal Changes in Perfusion in Elderly and Frontotemporal Dementia Patients

Tracy Ssali^1,2, Lucas Narciso^1,2, Matthais Günther³, Frank Prato^1,2, Udunna Anazodo^1,2, Elizabeth Finger⁴, and Keith St Lawrence^1,2

¹Lawson Health Research Institute, London, ON, Canada, ²Department of Medical Biophysics, Western University, London, ON, Canada, ³Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany, ⁴Department of Clinical Neurological Sciences, Western University, London, ON, Canada

Recent advances in the understanding of frontotemporal dementia (FTD) and subsequently, the development of novel disease modifying treatments, has stimulated the need for tools to assess treatment efficacy. While perfusion imaging by arterial spin labeling (ASL) is an attractive approach, its sensitivity to detect longitudinal changes in perfusion in dementia patients remains unknown. Longitudinal variability in perfusion was assessed on a voxel-by-voxel basis over a month. Power analysis revealed ASL has the sensitivity to longitudinal changes as low as 7-8%. These results highlight the potential of ASL for detecting longitudinal changes in FTD populations.

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