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Abstract #2595

Feasibility of Arterial Spin Labeling for Detection of Longitudinal Changes in Perfusion in Elderly and Frontotemporal Dementia Patients

Tracy Ssali1,2, Lucas Narciso1,2, Matthais G√ľnther3, Frank Prato1,2, Udunna Anazodo1,2, Elizabeth Finger4, and Keith St Lawrence1,2
1Lawson Health Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany, 4Department of Clinical Neurological Sciences, Western University, London, ON, Canada

Recent advances in the understanding of frontotemporal dementia (FTD) and subsequently, the development of novel disease modifying treatments, has stimulated the need for tools to assess treatment efficacy. While perfusion imaging by arterial spin labeling (ASL) is an attractive approach, its sensitivity to detect longitudinal changes in perfusion in dementia patients remains unknown. Longitudinal variability in perfusion was assessed on a voxel-by-voxel basis over a month. Power analysis revealed ASL has the sensitivity to longitudinal changes as low as 7-8%. These results highlight the potential of ASL for detecting longitudinal changes in FTD populations.

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