Three-dimensional variable-flip-angle (VFA) T1 mapping is a valuable T1 quantification method subject to a long scan time due to acquisition of multiple 3D images. SUPER (Shift Undersampling improves Parametric-mapping Efficiency and Resolution) is a recently developed method providing fast blockwise reconstruction for accelerated parametric mapping. Here we develop a combination of SUPER and 3D CAIPIRINHA to achieve 5-fold acceleration with 5 flip angles, validated with both retrospective and prospective reconstruction. The results suggest that the proposed method is highly accurate for accelerating 3D VFA T1 mapping, reducing the whole-brain scan time from 6 to 1.5 minutes.
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