Abstract #2696

The influence of undersampling scheme and labeling approach on functional arterial spin labeling with single-shot 3D GRASE readout at 3T

Dimo Ivanov¹, Josef Pfeuffer², Anna Gardumi¹, Kâmil Uludağ³, and Benedikt A Poser¹

¹Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, ²Siemens Healthineers, Erlangen, Germany, ³Techna Institute & Koerner Scientist in MR Imaging, Joint Department of Medical Imaging and Krembil Brain Institute, Toronto, ON, Canada

Arterial spin labeling (ASL) fMRI is beneficial, but suffers from low temporal signal-to-noise ratio (tSNR). We compared GRAPPA- and CAIPI-accelerated optimized short-TR single-shot 3D GRASE PASL and PCASL approaches at 3T. The CAIPI acceleration approach results in equally good or better results than the GRAPPA technique. Despite having higher perfusion tSNR, PCASL did not lead to significantly higher activation z-scores than PASL, reflecting the influence of larger number of samples for the latter. In conclusion, the higher (perfusion) tSNR efficiency of PCASL does not always guarantee outperformance and the best ASL fMRI approach will depend on the specific experimental parameters.

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