Abstract #2697

Improving task fMRI reliability at brain regions of high‐susceptibility using a multi-band PSF-mapping-based reverse-gradient approach

Myung-Ho In¹, Daehun Kang¹, Hang Joon Jo², Uten Yarach³, Joshua D Trzasko¹, Nolan K Meyer^1,4, Bardwell Speltz J Lydia ^1,4, John Huston III¹, Matt A Bernstein¹, and Yunhong Shu¹

¹Department of Radiology, Mayo Clinic, Rochester, MN, United States, ²Department of Physiology, College of Medicine, Hanyang University, Seoul, Korea, Republic of, ³Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, ⁴Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States

Interleaved reverse-gradient fMRI (RG-fMRI) with a PSF mapping-based distortion correction scheme has the potential to minimize the loss of signal in regions of rapid susceptibility change. Recently, multi-band imaging was combined to improve the temporal resolution for RG-fMRI, and the initial feasibility was evaluated in human. In this work, breath-holding task-fMRI was performed with the proposed scheme to demonstrate the effectiveness in improving fMRI reliability for each individual and the entire group, especially in high susceptibility brain regions.

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