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Abstract #2697

Improving task fMRI reliability at brain regions of high‐susceptibility using a multi-band PSF-mapping-based reverse-gradient approach

Myung-Ho In1, Daehun Kang1, Hang Joon Jo2, Uten Yarach3, Joshua D Trzasko1, Nolan K Meyer1,4, Bardwell Speltz J Lydia 1,4, John Huston III1, Matt A Bernstein1, and Yunhong Shu1
1Department of Radiology, Mayo Clinic, Rochester, MN, United States, 2Department of Physiology, College of Medicine, Hanyang University, Seoul, Korea, Republic of, 3Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, 4Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, MN, United States

Interleaved reverse-gradient fMRI (RG-fMRI) with a PSF mapping-based distortion correction scheme has the potential to minimize the loss of signal in regions of rapid susceptibility change. Recently, multi-band imaging was combined to improve the temporal resolution for RG-fMRI, and the initial feasibility was evaluated in human. In this work, breath-holding task-fMRI was performed with the proposed scheme to demonstrate the effectiveness in improving fMRI reliability for each individual and the entire group, especially in high susceptibility brain regions.

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