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Abstract #2716

Investigation of angiographic shine-through in time-encoded pCASL

Lena Vaclavu1, Dilek Betül Arslan2, Lydiane Hirschler1, Carles Falcon3,4, Esin Ozturk-Isik2, Juan Domingo Gispert3,4, Paula Montesinos5, Kim van de Ven6, and Matthias JP van Osch1
1Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 2Biomedical Engineering Institute, Boğaziçi University, Istanbul, Turkey, 3BarcelonaBeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain, 4CIBER-BBN, Madrid, Spain, 5Philips Healthcare Iberia, Madrid, Spain, 6Philips Healthcare, Best, Netherlands

Physiologic fluctuations can lead to the appearance of artefactual angiographic signal in the perfusion image of time-encoded pCASL previously dubbed “shine-through effect”. The aim of this study was to investigate the potential mechanisms inducing this artefact by characterizing the noise in time-encoded pCASL signal from individual Hadamard columns and rows as well as without labeling. We observed higher temporal standard deviation in the arteries compared to gray matter, and found that the shine-through effect was present even without labeling, suggesting that it is caused by the selective background suppression pulse applied close to acquisition time and the associated fresh inflow.

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