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Abstract #2742

Reliability of Arterial Spin Labeling derived Cerebral Blood Flow measurements in Periventricular White Matter

Sudipto Dolui1, Audrey P. Fan2,3, Moss Y. Zhao3, Greg Zaharchuk3, and John A. Detre1,4
1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Departments of Biomedical Engineering and Neurology, University of California, Davis, CA, United States, 3Department of Radiology, Stanford University, Palo Alto, CA, United States, 4Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Periventricular white matter (PVWM) is exclusively perfused by small vessels, and hence PVWM Cerebral Blood Flow (CBF) can provide a biomarker of cerebral small vessel functional integrity. Although PVWM is weakly perfused, we demonstrate that PVWM-CBF derived from state-of-the-art Arterial Spin Labeling (ASL) acquired twice ~15minutes apart in a cohort of 16 subjects showed high reproducibility that was comparable to other larger regions of interest. Further there was high correlation between PVWM-CBF derived from ASL and concurrently acquired [15O]-water Positron Emission Tomography data. These findings suggest that PVWM CBF can be reliably measured with advanced ASL methods.

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