Abstract #2742

Reliability of Arterial Spin Labeling derived Cerebral Blood Flow measurements in Periventricular White Matter

Sudipto Dolui¹, Audrey P. Fan^2,3, Moss Y. Zhao³, Greg Zaharchuk³, and John A. Detre^1,4

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Departments of Biomedical Engineering and Neurology, University of California, Davis, CA, United States, ³Department of Radiology, Stanford University, Palo Alto, CA, United States, ⁴Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States

Periventricular white matter (PVWM) is exclusively perfused by small vessels, and hence PVWM Cerebral Blood Flow (CBF) can provide a biomarker of cerebral small vessel functional integrity. Although PVWM is weakly perfused, we demonstrate that PVWM-CBF derived from state-of-the-art Arterial Spin Labeling (ASL) acquired twice ~15minutes apart in a cohort of 16 subjects showed high reproducibility that was comparable to other larger regions of interest. Further there was high correlation between PVWM-CBF derived from ASL and concurrently acquired [¹⁵O]-water Positron Emission Tomography data. These findings suggest that PVWM CBF can be reliably measured with advanced ASL methods.

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