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Abstract #2741

ASL perfusion and disability in primary progressive MS: an observational cohort study

Clara Delacour1, Ahmed-Ali El Ahmadi1, Gilles Brun1, Nadine Girard1,2, Christoph Heesen3,4, Arzu Ceylan Has3,4, and Jan-Patrick Stellmann2,3,4,5
1Neuroradiology, APHM La Timone, Marseille, France, 2Aix-Marseille Univ, CNRS, CRMBM, UMR 7339, Marseille, France, 3Institute of Neuroimmunology and MS (INIMS), University Medical Centre Hamburg-Eppendorf, Hamburg-Eppendorf, Germany, 4Neurology, University medical centre Hamburg-Eppendorf, Hamburg-Eppendorf, Germany, 5APHM La Timone, CEMEREM, Marseille, France

Disability progression in Multiple Sclerosis (MS) is driven by inflammation and neurodegeneration. Arterial spin labelling (ASL) is a non-invasive MRI method for the assessment of brain perfusion without the need for gadolinium. Here, we explored ASL perfusion as a biomarker for diseases progression and disability in a cohort of 77 patients with primary progressive MS (PPMS). While brain perfusion seemed rather stable during the follow-up of up to 5 years, we observed an association between higher regional perfusion rates and cognitive performance and hand functioning. Altered perfusion in PPMS seems thus not closely related to the major pathomechanism neurodegeneration.

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