We investigated the relationship between grey matter perfusion and clinical and conventional MRI measures in patients with relapsing multiple sclerosis (MS) to test the hypothesis that an impaired energy supply is associated with the development of brain damage and clinical disability. Using multi-inversion time pulsed ASL we demonstrated that MS patients have significantly lower cerebral grey matter perfusion when compared to healthy controls. In the patients, lower perfusion correlates with greater tendency to develop irreversible tissue damage and with worse clinical scores, suggesting that altered energy supply may directly contribute to damage and disability in MS.
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