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Abstract #2740

Relationship between global grey matter perfusion, damage and disability in multiple sclerosis

Daniele Mascali1, Antonio Maria Chiarelli1, Ilona Lipp2,3, Anna Digiovanni4, Valentina Tomassini1,3,4, and Richard Geoffrey Wise1,3
1Institute for Advanced Biomedical Technologies,Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio University" of Chieti-Pescara, Chieti, Italy, 2Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 3Cardiff University Brain Research Imaging Centre (CUBRIC) School of Psychology, Cardiff University, Cardiff, United Kingdom, 4MS Centre, Neurology Unit, SS. Annunziata University Hospital, Chieti, Italy

We investigated the relationship between grey matter perfusion and clinical and conventional MRI measures in patients with relapsing multiple sclerosis (MS) to test the hypothesis that an impaired energy supply is associated with the development of brain damage and clinical disability. Using multi-inversion time pulsed ASL we demonstrated that MS patients have significantly lower cerebral grey matter perfusion when compared to healthy controls. In the patients, lower perfusion correlates with greater tendency to develop irreversible tissue damage and with worse clinical scores, suggesting that altered energy supply may directly contribute to damage and disability in MS.

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