The present study was to explore regional perfusion changes in patients with Parkinson's disease dementia (PDD) and Alzheimer’s disease (AD) using 3D arterial spin labeling MRI and further assess the corresponding difference between PDD and AD patients. The results revealed that the perfusion pattern in PDD group was distinct from that in AD group despite of overlapped perfusion regions. The resultant normalized cerebral blood flow (CBF) can distinguish PDD from AD. Therefore, normalized CBF provided sensitive imaging-based markers that contribute to the diagnosis and differential diagnosis of the two dementia.
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