Abstract #2738

Depicting the developmental trajectories of brain cerebral blood flow using 3D ASL in children aged 28 days to 15 years.

Peiyao Chen¹, Chao Jin¹, Xianjun Li¹, Miaomiao Wang¹, Congcong Liu¹, Xiaoyu Wang¹, Fan Wu¹, Yuli Zhang¹, Cong Tian¹, Mengxuan Li¹, Xiaocheng Wei², and Jian Yang¹

¹First Affiliated Hospital of Xi 'an Jiaotong University, Xi'an, Shaanxi, China, ²MR Research China, GE Healthcare, Beijing, China

Adequate cerebral blood flow (CBF) is essential for development of brain structure and function. However, little is known about the developmental trajectory of CBF across the broad age range in childhood. This study aims to investigate the spatiotemporal evolution of CBF in cerebral cortex and basal ganglia in healthy term children aged from 28 days to 15 years. Our results indicated that the estimated age with highest CBF was earliest in the occipital lobe, followed by temporal and parietal lobe, at last in the frontal lobe. The perfusion of basal ganglia showed a U-shaped curve, which slowly increased with age.

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