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Abstract #2744

Moving Towards Robust Quantification of Cerebrovascular Reactivity (CVR) using Pseudocontinuous Arterial Spin Labelling (pCASL)

Colette C. Milbourn1, Thomas W. Okell2, and Nicholas P. Blockley1
1The School of Life Sciences, University of Nottingham, Nottingham, United Kingdom, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

New clinical tools are needed for the diagnosis and prognosis of cerebrovascular diseases. Pseudocontinuous Arterial Spin Labelling (pCASL) is recommended for quantifying tissue cerebral blood flow due to its superior signal-to-noise. Stressors to the brain like high carbon dioxide (hypercapnia), used to map Cerebrovascular Reactivity (CVR), are known to reduce the labelling efficiency of pCASL and therefore underestimate CVR. In this study a systematic difference in CVR was observed across measurements made with three different sets of pCASL parameters. Ultimately this work will help to determine pCASL parameters that minimise systematic error and produce robust quantitative estimates of CVR.

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