Meeting Banner
Abstract #2745

Arterial Spin Labeling Can Identify Cerebrovascular Reactivity Deficit in Patients with Vasculopathy: A Pilot Study Using Simultaneous PET/MRI

Moss Y Zhao1, Audrey P Fan2, David Chen3,4, Jia Guo5, Yosuke Ishii6, David Shin7, Mohammad Mehdi Khalighi1, Dawn Holley1, Kim Halbert1, Andrea Otte1, Brittney Williams1, Jun-Hyung Park1, Bin Shen1, Gary Steinberg8, and Greg Zaharchuk1
1Radiology, Stanford University, Stanford, CA, United States, 2Biomedical Engineering and Neurology, University of California Davis, Davis, CA, United States, 3Medical Imaging, Taipei Medical University – Shuan-Ho Hospital, New Taipei City, Taiwan, 4Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 5Bioengineering, University of California Riverside, Riverside, CA, United States, 6Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan, 7GE Healthcare, Melo Park, CA, United States, 8Neurosurgery, Stanford University, Stanford, CA, United States

Cerebrovascular reactivity (CVR) reflects the capacity of the brain to respond to external stress. Impaired CVR leads to a higher risk of stroke. The standard CVR measuring tool relied on PET imaging but is inaccessible to most patients. Here we investigate the CVR of Moyamoya patients using arterial spin labeling (ASL), a non-invasive and quantitative MRI technique. Results showed that significant lower CVR was found in flow territories with severe stenosis or occlusion, making ASL a potential diagnostic tool to predict the risk of stroke for patients with vasculopathy.

This abstract and the presentation materials are available to members only; a login is required.

Join Here