Abstract #2745

Arterial Spin Labeling Can Identify Cerebrovascular Reactivity Deficit in Patients with Vasculopathy: A Pilot Study Using Simultaneous PET/MRI

Moss Y Zhao¹, Audrey P Fan², David Chen^3,4, Jia Guo⁵, Yosuke Ishii⁶, David Shin⁷, Mohammad Mehdi Khalighi¹, Dawn Holley¹, Kim Halbert¹, Andrea Otte¹, Brittney Williams¹, Jun-Hyung Park¹, Bin Shen¹, Gary Steinberg⁸, and Greg Zaharchuk¹

¹Radiology, Stanford University, Stanford, CA, United States, ²Biomedical Engineering and Neurology, University of California Davis, Davis, CA, United States, ³Medical Imaging, Taipei Medical University – Shuan-Ho Hospital, New Taipei City, Taiwan, ⁴Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁵Bioengineering, University of California Riverside, Riverside, CA, United States, ⁶Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan, ⁷GE Healthcare, Melo Park, CA, United States, ⁸Neurosurgery, Stanford University, Stanford, CA, United States

Cerebrovascular reactivity (CVR) reflects the capacity of the brain to respond to external stress. Impaired CVR leads to a higher risk of stroke. The standard CVR measuring tool relied on PET imaging but is inaccessible to most patients. Here we investigate the CVR of Moyamoya patients using arterial spin labeling (ASL), a non-invasive and quantitative MRI technique. Results showed that significant lower CVR was found in flow territories with severe stenosis or occlusion, making ASL a potential diagnostic tool to predict the risk of stroke for patients with vasculopathy.

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