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Abstract #2748

Mapping water exchange rate change after caffeine uptake using 3D diffusion prepared arterial spin labeled perfusion MRI

Qihao Zhang1, Jana Ivanidze2, Thanh Nguyen2, Pascal Spincemaille2, and Yi Wang1
1Cornell University, New York, NY, United States, 2Weill Cornell Medical College, New York, NY, United States

We propose to exam the water exchange rate (kw) change after caffeine uptake based on an optimized diffusion prepared arterial spin labeling (ASL) sequence and reconstruction method in a previous work1. 5 subjects went through two scans to test the reproducibility of the reconstruction pipeline. Another 5 subjects are scanned before and half an hour after caffeine uptake. Cerebral blood flow (CBF) and are reconstructed from the ASL images. A 26% decrease in CBF and 13% decrease of kw is observed.

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