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Abstract #2751

Measurement of Pulmonary Perfusion under Expiratory and Inspiratory Breathing Conditions using PCASL-bSSFP Imaging at 1.5 Tesla

Petros Martirosian1, Rolf Pohmann2, Martin Schwartz1,3, Thomas Kuestner4, Manuel Kolb4, Ahmed Othman4, Cecilia Zhang4, Klaus Scheffler2,5, Konstantin Nikolaou4, Fritz Schick1, and Ferdinand Seith4
1Section on Experimental Radiology, University of Tübingen, Tübingen, Germany, 2Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Institute of Signal Processing and System Theory, University of Stuttgart, Stuttgart, Germany, 4Department of Diagnostic and Interventional Radiology, University of Tübingen, Tübingen, Germany, 5Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany

Pseudo-continuous-arterial-spin-labeling (PCASL) has been successfully applied in the lung providing high quality perfusion images. The pulmonary blood flow and the respiratory system interact closely: the intrathoracic pressure has impact on the venous return. Therefore, in this work, we evaluate the effects of intrathoracic pressure on lung perfusion by using PCASL imaging in end-expiratory and end-inspiratory breath-hold. PCASL imaging is able to detect changes of parenchymal lung perfusion caused by alterations of the intrathoracic pressure. Perfusion signal measured under end-inspiratory condition were noticeably reduced as compared to end-expiratory breath-hold. This correlated significantly with measured blood flow volume through the pulmonary trunk.

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