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Abstract #2763

Multiparametric magnetic resonance imaging of liver regeneration in rabbits with warm ischemia-reperfusion injury

Zhengzheng Tao1,2, Zhiqiang Chu3, Jiabing Jiang1,2, Qing He1,2, Jinxia Zhu4, Robert Grimm5, and Qian Ji2
1First Central Clinical College of Tianjin Medical University, Tianjin, China, 2Department of Radiology, Tianjin First Central Hospital, Tianjin, China, 3Department of Transplantation, Tianjin First Central Hospital, Tianjin, China, 4MR Collaboration, Siemens Healthcare, Beijing, China, 5Siemens Healthcare GmbH, Erlangen, Germany

Multiparametric magnetic resonance imaging (MRI) provides various noninvasive and quantitative diagnostic information. This study assessed the value of multiparametric MRI in liver regeneration after warm ischemic-reperfusion injury (WIRI) in a rabbit model with different warm ischemia and reperfusion times. The results showed that the tissue diffusivity (Dslow), pseudo-diffusion coefficient (Dfast), perfusion fraction (PF), apparent diffusion coefficient (ADC), fractional anisotropy (FA), and R2* maps reflected changes in hepatic microcirculation perfusion, micro-dispersion, and oxygenation of hepatic WIRI after partial hepatectomy. Liver regeneration capacities were enhanced when warm ischemia times were 30 minutes or less; however, they were diminished after 30 minutes.

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