Drug Induced Liver Injury causes liver failure and impedes drug development, and Drug-Drug Interactions affect the pharmacokinetics of drug metabolism and excretion. Non-invasive biomarkers are needed to monitor these processes. We used gadoxetate DCE-MRI to measure clinical and high dose rifampicin effects on hepatocellular uptake in acute and chronic dosing regimens in rats. High dose rifampicin caused significantly reduced gadoxetate uptake acutely, whereas uptake rates returned to baseline values after chronic dosing. Similar but non-significant effects were seen at clinical dose levels. We demonstrated the potential of gadoxetate DCE-MRI to non-invasively assess drug-induced inhibition of hepatocellular transport and DDIs.
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