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Abstract #2777

Feasibility of amide proton transfer imaging on distinction of the vertebral body and paravertebral muscles in patients with CKD

Yan Xiong1, Weiyin Vivian Liu2, Tongxiang He1, Donglin Wen 1, Fan He1, and Xiaoming Li3
1Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, 2MR Research, GE Healthcare, Beijing, China, 31Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. Due to decreased vascular perfusion and increased glycolytic metabolism, tissue hypoxia is usually accompanied by acidosis; however, osteoclasts show significant functional enhancement in hypoxia and acidosis. The present study demonstrates that APT had higher diagnostic performance on identifying the differences of both bone and muscles between patients with different levels of CKD. It may have potential in distinction patients with CKD in accompanied with Mineral bone disease (MBD).

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