Amide proton transfer-weighted (APTw) imaging is a molecular MRI technique that generates image contrast based predominantly on the amide protons in mobile cellular proteins and peptides that are endogenous in tissue. Due to decreased vascular perfusion and increased glycolytic metabolism, tissue hypoxia is usually accompanied by acidosis; however, osteoclasts show significant functional enhancement in hypoxia and acidosis. The present study demonstrates that APT had higher diagnostic performance on identifying the differences of both bone and muscles between patients with different levels of CKD. It may have potential in distinction patients with CKD in accompanied with Mineral bone disease (MBD).
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