Meeting Banner
Abstract #2783

High temporal-resolution dynamic MRI for the assessment of brown adipose tissue during mild-cold exposure in young healthy adults.

Aashley S.D. Sardjoe Mishre1, Maaike E. Straat2, Borja M. Martinez-Tellez2, Oleh Dzyubachyk3, Mariette R. Boon2, Patrick C.N. Rensen2, Andrew G. Webb1, and Hermien E. Kan1
1Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center (LUMC), Leiden, Netherlands, 2Department of Medicine, Division of Endocrinology and Einthoven Laboratory for Experimental Vascular Medicine, LUMC, Leiden, Netherlands, 3Department of Radiology, Division of Image Processing (LKEB) and Department of Cell and Chemical Biology, Electron Microscopy section, LUMC, Leiden, Netherlands

Brown adipose tissue (BAT) is considered as a potential therapeutic target against cardiometabolic diseases. Activated BAT combusts fatty acids leading to a reduction in fat fraction (FF). Both cold exposure and pharmacological stimuli can activate BAT, but the short-term dynamics of BAT activation are still unknown. To assess supraclavicular BAT (scBAT) FF dynamics during cold-exposure, we developed a 1-minute time resolution MRI protocol using breath-holds and co-registration to minimize motion-artefacts, and tested the protocol in five individuals. Co-registration resulted in low variation (<0.5%) and dynamic FF changes during cooling differed between subjects, possibly due to variable responses to thermoneutral conditions.

This abstract and the presentation materials are available to members only; a login is required.

Join Here