1H-MRS has been widely used to measure total intrahepatic lipid content, but measuring lipid composition with specifically differentiating saturated, mono- and poly-unsaturated fatty acids in the liver, is challenging. At clinical field strength (3T), the allylic peak is overlapping with the alpha-carbonyl methylene resonance, which we recently addressed with a sophisticated fitting routine. However, this approach is difficult when shimming is suboptimal or in volunteers with low liver fat content (1-2%). Here, we evaluated the in vivo feasibility of J-difference editing, using MEGA-sLASER in the liver, to separate allylic from the alpha-carbonyl resonance for estimation of hepatic lipid composition.
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