Abstract #2798

Structural connectivity is more sensitive to track cognition progression individual level than fMRI and MEG over 2 years in mildly disabled RRMS

Arzu Ceylan Has Silemek¹, Guido Nolte², Jana Pöttgen^1,3, Andreas K. Engel⁴, Christoph Heesen^1,3, Stefan M. Gold^1,5, and Jan-Patrick Stellmann^6,7

¹Institute of Neuroimmunology and Multiple Sclerosis (INIMS), University Medical Center Eppendorf, Hamburg, Germany, ²Department of Neurophysiology and Pathophysiology, University Medical Center Eppendorf, Hamburg, Germany, ³Department of Neurology, University Medical Center Eppendorf, Hamburg, Germany, ⁴Institute of Neurophysiology and Pathophysiology, University Medical Center Eppendorf, Hamburg, Germany, ⁵Department of Psychiatry and Psychotherapy, Charité University Medical Center, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany, ⁶CRMBM AMU-CNRS, Aix-Marseille Université, Marseille, France, ⁷CEMEREM, APHM, CHU Timone, Marseille, France

There is still substantial inconsistency between clinical disabilities and findings on brain networks and lack of longitudinal study in Multiple Sclerosis (MS). We aimed to elucidate how topology alters and how disability progression affects the structural and functional organizations over 2-years using graph theory approach in relapsing-remitting MS (RRMS). RRMS patients have encountered with lack of improvement in PASAT over 2-years. Structural connectivity was more sensitive to show a relationship with a cognitive function over 2-years than the rs-fMRI and MEG functional metrics in RRMS patients. These findings underline the difficulties associated with functional imaging studies in MS.

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