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Abstract #2797

3.0 T MRI detects brain ventricle oscillations in patients with clinically-isolated syndrome

Jason Michael Millward1, Claudia Chien2, Joseph Kuchling2, Friedemann Paul2, Thoralf Niendorf1, and Sonia Waiczies1
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany

We used clinical high resolution 3T MRI to investigate brain ventricle changes over time in patients with clinically isolated syndrome (CIS) who are at the early stages of disease, which may eventually become multiple sclerosis. While most patients showed an overall increase in ventricle volume, 23% also showed contractions greater than the range of variation in healthy subjects, even over a period of years. Patients with contracting ventricles were significantly younger than those without. This suggests that, in addition to neurodegeneration, other processes are implicated that lead to a transient enlargement of the ventricles, which then later resolves.

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