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Abstract #2796

T1 abnormalities in atlas-based white matter tracts: reducing the clinico-radiological paradox in multiple sclerosis using qMRI

Veronica Ravano1,2,3, Gian Franco Piredda1,2,3, Manuela Vaneckova4, Jan Krasensky4, Michaela Andelova5, Tomas Uher5, Barbora Srpova5, Eva Kubala Havrdova5, Karolina Vodehnalova5, Dana Horakova5, Tom Hilbert1,2,3, Bénédicte Maréchal1,2,3, Reto Meuli2, Jean-Philippe Thiran2,3, Tobias Kober1,2,3, and Jonas Richiardi2
1Advanced Clinical Imaging Technology, Siemens Healthineers, Lausanne, Switzerland, 2Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 3LTS5, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 4Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic, 5Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

In multiple sclerosis, standard radiological metrics (i.e. lesion load) correlate poorly with clinical outcomes. To overcome this limitation, we propose a novel method to evaluate T1 relaxometry abnormalities along thirty-seven major white matter pathways extracted from a tractography atlas, i.e. without needing a diffusion scan. Evaluating T1 z-scores along WM tracts strongly improved correlation with disability compared to lesion load. The strongest correlations were found for T1 abnormalities in normal-appearing white matter, especially in infratentorial tracts. These results suggest that diffuse pathological changes in normal-appearing WM measured along atlas-based tracts using T1 relaxometry could aid clinical evaluation of multiple sclerosis.

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