Abstract #2795

Periventricular gradients of brain pathology in early and progressive MS revealed by qMRI

Gian Franco Piredda^1,2,3, Tom Hilbert^1,2,3, Manuela Vaneckova⁴, Jan Krasensky⁴, Michaela Andelova⁵, Tomas Uher⁵, Barbora Srpova⁵, Eva Kubala Havrdova⁵, Karolina Vodehnalova⁵, Dana Horakova⁵, Veronica Ravano^1,2,3, Bénédicte Maréchal^1,2,3, Jean-Philippe Thiran^2,3, and Tobias Kober^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Poland, ⁵Department of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Poland

In multiple sclerosis, gradients of tissue damage severity were found in periventricular areas and proved to change in response to treatment. This work investigates whether these gradual microstructural changes can be detected with high-resolution, whole-brain quantitative T₁ mapping and how they compare between two cohorts of early and progressive multiple sclerosis patients. T₁ deviations were computed in patients from normative atlases established in a healthy cohort and corrected for age and gender. Results show that a periventricular gradient of abnormal T₁ values in normal-appearing white matter is indeed present and increases from early to progressive stages of the disease.

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