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Abstract #2794

Diffusely abnormal white matter in clinically isolated syndrome is associated with parenchymal loss and elevated neurofilament levels

Irene Margaret Vavasour1, Jackie T Yik2,3, Pierre Becquart4, Jasmine Gill4, Shannon H Kolind1,2,3,5, Alice J Schabas5, Ana-Luiza Sayao5, Virginia Devonshire5, Robert Carruthers5, Anthony Traboulsee5, GR Wayne Moore3,4,5, Sophie Stukas4, Cheryl Wellington4, Jacqueline Quandt4, David KB Li1, and Cornelia Laule1,2,3,4
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada, 4Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 5Medicine, University of British Columbia, Vancouver, BC, Canada

We characterized the frequency of diffusely abnormal white matter (DAWM) in a broad cohort of multiple sclerosis (MS) participants. 35% of clinically isolated syndrome (CIS) and ~60% of MS participants had DAWM. CIS with DAWM had smaller cortical thickness, higher lesion load and higher concentration of neurofilament light chain compared to CIS without DAWM. DAWM may be useful in identifying brains at risk of injury but only in the CIS population when lesion load is low. Longitudinal studies are warranted.

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