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Abstract #2793

Hippocampal subfield volumes relate to future cognitive performance in Multiple Sclerosis 

Katherine A Koenig1, Jian Lin1, Daniel Ontaneda1, Kedar Mahajan1, Jenny Feng1, Stephen Rao1, Sanghoon Kim1, Stephen Jones1, and Mark J Lowe1
1The Cleveland Clinic, Cleveland, OH, United States

Cognitive dysfunction is a common symptom of Multiple Sclerosis (MS), and patients would benefit from a measure that estimates their risk of future decline. Previous work suggests that hippocampal subfield volumes may have value as a predictive measure. Using 7 tesla MRI, we measured hippocampal volumes in 77 participants with MS. We found relationships between subfield volumes and future cognitive performance. These relationships were driven by relapse remitting MS patients, although the secondary progressive MS group did not show clear differences in the relationship patterns.

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