Cognitive dysfunction is a common symptom of Multiple Sclerosis (MS), and patients would benefit from a measure that estimates their risk of future decline. Previous work suggests that hippocampal subfield volumes may have value as a predictive measure. Using 7 tesla MRI, we measured hippocampal volumes in 77 participants with MS. We found relationships between subfield volumes and future cognitive performance. These relationships were driven by relapse remitting MS patients, although the secondary progressive MS group did not show clear differences in the relationship patterns.
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