Meeting Banner
Abstract #2792

Greater increase in magnetic susceptibility following acute MS lesion formation is associated with reduced myelin repair

Lily Zexter1, Thanh D. Nguyen2, Elizabeth M. Sweeney3, Yi Wang2, and Susan A. Gauthier1
1Department of Neurology, Weill Cornell Medicine, New York, NY, United States, 2Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 3Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States

Quantitative susceptibility mapping (QSM) provides an effective means to directly map the distribution of magnetic susceptibility sources, such as brain iron. In this study, we examined the relationship between initial QSM change and short-term myelin recovery, measured by myelin water fraction (MWF). The results showed that change in lesion susceptibility at three months was significantly and negatively associated with change in MWF at one year. This significant association provides evidence of the damaging effect of brain iron during early stages of lesion development.

This abstract and the presentation materials are available to members only; a login is required.

Join Here