Quantitative susceptibility mapping (QSM) provides an effective means to directly map the distribution of magnetic susceptibility sources, such as brain iron. In this study, we examined the relationship between initial QSM change and short-term myelin recovery, measured by myelin water fraction (MWF). The results showed that change in lesion susceptibility at three months was significantly and negatively associated with change in MWF at one year. This significant association provides evidence of the damaging effect of brain iron during early stages of lesion development.
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