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Abstract #2791

Tracking longitudinal disease progression of MS during fingolimod therapy using SFCI, a combined structural and functional connectivity metric

Pallab K Bhattacharyya1, Robert Fox1, Jian Lin1, Paola Raska1, Ken Sakaie1, and Mark J Lowe1
1Cleveland Clinic Foundation, CLEVELAND, OH, United States

It has been reported that structural and functional connectivity impairment of motor and cognitive network in multiple sclerosis (MS), as measured by diffusion tensor imaging (DTI) and functional connectivity (fcMRI) respectively, stabilize after one year of fingolimod treatment. Structural and functional connectivity index (SFCI), a combined metric of DTI and fcMRI has previously been demonstrated as a sensitive imaging-based measure of progression of MS. Change of (i) motor (ii) cognitive and (iii) pathway combined SFCI were tracked over 2-year fingolimod therapy of MS. SFCI stabilized after one year, which shows its effectiveness to measure disease progression following therapy .

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