Sex difference in multiple sclerosis (MS) prevalence is well recognized but impacts on tissue microstructure and its variations with respect to disease modifying therapies (DMTs) remains unclear. Here we investigated sex-based differences in lesion microstructure and its variations with therapeutic approaches in 52 relapsing-remitting MS patients using diffusion tensor, compartment, and orientation models. We found that men had greater myelin and axonal damage than women in MS lesions, and there was less axonal damage in women taking oral versus injectable DMTs. These results may support further investigations of sex-driven differences in disease monitoring and treatment choices to promote personalized medicine.
This abstract and the presentation materials are available to members only; a login is required.