Abstract #2790

Sex-based differences in tissue microstructure in multiple sclerosis detected using multi-model diffusion MRI

Olayinka Adeoluwa Oladosu¹, Cayden Murray², Syed Rizvi², Mariana Bento^3,4, G Bruce Pike^3,4, and Yunyan Zhang^3,4

¹Neuroscience, University of Calgary, Calgary, AB, Canada, ²University of Calgary, Calgary, AB, Canada, ³Radiology, University of Calgary, Calgary, AB, Canada, ⁴Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

Sex difference in multiple sclerosis (MS) prevalence is well recognized but impacts on tissue microstructure and its variations with respect to disease modifying therapies (DMTs) remains unclear. Here we investigated sex-based differences in lesion microstructure and its variations with therapeutic approaches in 52 relapsing-remitting MS patients using diffusion tensor, compartment, and orientation models. We found that men had greater myelin and axonal damage than women in MS lesions, and there was less axonal damage in women taking oral versus injectable DMTs. These results may support further investigations of sex-driven differences in disease monitoring and treatment choices to promote personalized medicine.

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