Abstract #2802

Assessment of white matter damages in Multiple Sclerosis using normative templates of conventional and inhomogeneous Magnetization Transfer

Lucas Soustelle^1,2, Andreea Hertanu^1,2, Arnaud Le Troter^1,2, Soraya Gherib^1,2, Samira Mchinda^1,2, Patrick Viout^1,2, Lauriane Pini^1,2, Claire Costes^1,2, Sylviane Confort-Gouny^1,2, Adil Maarouf^1,2,3, Bertrand Audoin^1,2,3, Audrey Rico^1,2,3, Clémence Boutière^1,2,3, Maxime Guye^1,2, Jean-Philippe Ranjeva^1,2, Gopal Varma⁴, David C. Alsop⁴, Jean Pelletier^1,2,3, Guillaume Duhamel^1,2, and Olivier M. Girard^1,2

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³APHM, Hôpital Universitaire Timone, Service de neurologie, Marseille, France, ⁴Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Characterization of Multiple Sclerosis (MS) is of paramount importance for patient care. In this work, we compare inhomogeneous (ihMT) and conventional magnetization transfer (MT) MRI techniques for white matter (WM) evaluation in a group comparison analysis after normalization in a standard space (templates of MS patients and healthy controls). Regions of interest, voxel-based morphometry and histogram analyses revealed that signal changes in pathological WM are not equivalent for ihMT and MT, highlighting that both metrics provide complementary information.

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