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Abstract #2802

Assessment of white matter damages in Multiple Sclerosis using normative templates of conventional and inhomogeneous Magnetization Transfer

Lucas Soustelle1,2, Andreea Hertanu1,2, Arnaud Le Troter1,2, Soraya Gherib1,2, Samira Mchinda1,2, Patrick Viout1,2, Lauriane Pini1,2, Claire Costes1,2, Sylviane Confort-Gouny1,2, Adil Maarouf1,2,3, Bertrand Audoin1,2,3, Audrey Rico1,2,3, Clémence Boutière1,2,3, Maxime Guye1,2, Jean-Philippe Ranjeva1,2, Gopal Varma4, David C. Alsop4, Jean Pelletier1,2,3, Guillaume Duhamel1,2, and Olivier M. Girard1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3APHM, Hôpital Universitaire Timone, Service de neurologie, Marseille, France, 4Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Characterization of Multiple Sclerosis (MS) is of paramount importance for patient care. In this work, we compare inhomogeneous (ihMT) and conventional magnetization transfer (MT) MRI techniques for white matter (WM) evaluation in a group comparison analysis after normalization in a standard space (templates of MS patients and healthy controls). Regions of interest, voxel-based morphometry and histogram analyses revealed that signal changes in pathological WM are not equivalent for ihMT and MT, highlighting that both metrics provide complementary information.

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Abstract