Abstract #2803

Assessing proximal and distal peripheral nerve damage in relapsing-remitting multiple sclerosis using magnetisation transfer ratio

Marios C. Yiannakas¹, Ratthaporn Boonsuth¹, Carmen Tur^1,2, Marco Battiston¹, Francesco Grussu^1,3, Rebecca S. Samson¹, Torben Schneider⁴, Masami Yoneyama⁵, Ferran Prados^1,6,7, Sara Collorone¹, Rosanna Cortese¹, Olga Ciccarelli¹, and Claudia A. M. Gandini Wheeler-Kingshott^1,8,9

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Fuculty of Brain Sciences, University College London, London, United Kingdom, ²Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Institute of Research, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain, ³Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, ⁴Philips Healthcare, Surrey, Guildford, United Kingdom, ⁵Philips Japan, Minatoku, Tokyo, Japan, ⁶Centre for Medical Image Computing, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁷Universitat Oberta de Catalunya, Barcelona, Spain, ⁸Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁹Brain Connectivity Research Centre, IRCCS Mondino Foundation, Pavia, Italy

Whilst multiple sclerosis (MS) is thought to be a disease of the central nervous system, evidence from neuropathological investigations has demonstrated that the peripheral nervous system (PNS) can also be affected in MS, with demyelination and axonal degeneration being the main pathophysiological mechanisms involved. In this study, PNS damage is assessed in vivo at proximal (lumbar plexus) and distal (sciatic nerve) anatomical locations in people with relapsing-remitting MS and healthy controls using magnetisation transfer ratio (MTR). Results demonstrate significantly reduced MTR values at distal anatomical locations, however no relationship is identified between these changes and clinical scores of disability.

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