Whilst multiple sclerosis (MS) is thought to be a disease of the central nervous system, evidence from neuropathological investigations has demonstrated that the peripheral nervous system (PNS) can also be affected in MS, with demyelination and axonal degeneration being the main pathophysiological mechanisms involved. In this study, PNS damage is assessed in vivo at proximal (lumbar plexus) and distal (sciatic nerve) anatomical locations in people with relapsing-remitting MS and healthy controls using magnetisation transfer ratio (MTR). Results demonstrate significantly reduced MTR values at distal anatomical locations, however no relationship is identified between these changes and clinical scores of disability.
This abstract and the presentation materials are available to members only; a login is required.