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Abstract #2808

Prediction of multiple sclerosis clinical progression using whole brain adiabatic T1rho and Relaxation Along a Fictitious Field imaging

Ivan Jambor1, Aida Steiner2, Marko Pesola3, Timo Liimatainen4, Marcus Sucksdorff3, Eero Rissanen 2, Laura Airas2, Hannu Aronen3, and Harri Merisaari3
1Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Turku University Hospital, Turku, Finland, 3University of Turku, Turku, Finland, 4University of Oulu, Oulu, Finland

In this single center prospective clinical trial, we have shown feasibility of whole brain of T1ρadiab and TRAFF2 at 3T. Both of these methods provided higher lesion-to-normal appearing white matter contrast compared with conventional used T1-weighted imaging, and demonstrated potential to predict multiple sclerosis disease severity scores (EDSS, MSSS) at the time of imaging and 1-year follow-up. These encouraging findings stimulate further application of T1ρadiab and TRAFF2 at 3T in patients with multiple sclerosis.

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