In this single center prospective clinical trial, we have shown feasibility of whole brain of T1ρadiab and TRAFF2 at 3T. Both of these methods provided higher lesion-to-normal appearing white matter contrast compared with conventional used T1-weighted imaging, and demonstrated potential to predict multiple sclerosis disease severity scores (EDSS, MSSS) at the time of imaging and 1-year follow-up. These encouraging findings stimulate further application of T1ρadiab and TRAFF2 at 3T in patients with multiple sclerosis.
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