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Abstract #2827

Mapping myelin content in ex-vivo MS brain tissue using short-T2 MRI of the lipid-protein bilayer

Emily Louise Baadsvik1, Markus Weiger1, Romain Froidevaux1, Wolfgang Faigle2, Benjamin Victor Ineichen2, and Klaas Paul Pruessmann1
1ETH Zurich and University of Zurich, Zurich, Switzerland, 2University Hospital Zurich and University of Zurich, Zurich, Switzerland

Ultrashort-T2 signal from white matter can be captured for imaging using dedicated short-T2 techniques. In this work, such methods were applied to D2O-exchanged human brain tissue from four donors diagnosed with multiple sclerosis to obtain 0.39 mm isotropic resolution MR images of the ultrashort-T2 tissue components and a lower-resolution multi-TE image series which, via a model fitting procedure, was used to produce maps of the relative content of myelin lipid-protein bilayer. As proof-of-principle, the contrast in these images was compared with corresponding myelin-stained cryosections and sample photographs, yielding promising correlation for white matter, grey matter and multiple sclerosis lesions.

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