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Abstract #2828

Myelin imaging derived quantitative parameter mapping compared to myelin water fraction

Yuki Kanazawa1, Masafumi Harada1, Yo Taniguchi2, Syun Kitano3, Nagomi Fukuda3, Yuki Matsumoto1, Hiroaki Hayashi4, Kosuke Ito2, Yoshitaka Bito2, and Akihiro Haga1
1Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan, 2Healthcare Business Unit, Hitachi, Ltd., Tokyo, Japan, 3Faculty of Medicine, Tokushima University, Tokushima, Japan, 4Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

We evaluated myelin imaging R1·R2* derived from QPM-relaxation parameters compared with the MWF derived from the same QPM gradient-echo dataset. Linear regression analysis indicated a correlation between R1·R2* products values and MWF values derived from same QPM dataset (R = 0.53, P < 0.0001).The R1·R2* products map derived from QPM offers as follow advantage; quantitative analysis; artifact free; and post-processing without fitting algorithm after QPM estimation. Myelin map derived from QPM can be applied for the quantitative assessment of white matter structure as substitute for MWF.

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