Abstract #2828

Myelin imaging derived quantitative parameter mapping compared to myelin water fraction

Yuki Kanazawa¹, Masafumi Harada¹, Yo Taniguchi², Syun Kitano³, Nagomi Fukuda³, Yuki Matsumoto¹, Hiroaki Hayashi⁴, Kosuke Ito², Yoshitaka Bito², and Akihiro Haga¹

¹Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan, ²Healthcare Business Unit, Hitachi, Ltd., Tokyo, Japan, ³Faculty of Medicine, Tokushima University, Tokushima, Japan, ⁴Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

We evaluated myelin imaging R₁·R₂^* derived from QPM-relaxation parameters compared with the MWF derived from the same QPM gradient-echo dataset. Linear regression analysis indicated a correlation between R₁·R₂^*products values and MWF values derived from same QPM dataset (R = 0.53, P < 0.0001).The R₁·R₂^* products map derived from QPM offers as follow advantage; quantitative analysis; artifact free; and post-processing without fitting algorithm after QPM estimation. Myelin map derived from QPM can be applied for the quantitative assessment of white matter structure as substitute for MWF.

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