Abstract #2829

Association of estimated time from the onset of multiple sclerosis plaques with myelin and axon-related quantitative MRI measurement

Tomoko Maekawa^1,2, Akifumi Hagiwara^1,3, Masaaki Hori^1,4, Christina Andica¹, Shohei Fujita^1,5, Toshiaki Akashi¹, Koji Kamagata¹, Akihiko Wada¹, and Shigeki Aoki¹

¹Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Division of Regenerative Medicine, The Jikei University School of Medicine, Tokyo, Japan, ³Department of Radiological Science, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States, ⁴Department of Diagnostic Radiology, Toho University Omori Medical Center, Tokyo, Japan, ⁵Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

We investigated the association between estimated time from the onset of multiple sclerosis (MS) plaques and myelin- and axon-related quantitative MRI measurements using synthetic MRI (SyMRI) and neurite orientation dispersion and density imaging (NODDI). We retrospectively analyzed 32 MS patients with 73 newly appearing plaques. MS plaques with longer estimated time from the onset had significantly lower myelin volume fraction and higher g-ratio. It is suggested that myelin in plaques is under ongoing damage more than axons. SyMRI and NODDI may be useful for the quantitative assessment of temporal change in MS plaques.

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