Realistic synthetic PRESS spectra were generated for three different echo times for each of the three major vendors. These spectra were then fit to the matched basis set (i.e., the basis set used to generate it), as well as the mismatched basis sets at the same echo time from other vendors, and the matched basis set but with the hard pulse approximation, to investigate how sensitive resulting quantification is to basis sets. It was found that the concentration for low-concentration metabolites is highly susceptible to small changes in basis sets (e.g., GABA varied by 115 ± 188%).
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