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Abstract #2839

Discrimination of tumor texture based on MRI radiomic features: is there a volume threshold? A phantom study.

Linda Bianchini1, João Santinha2,3, Francesca Botta4, Daniela Origgi4, Marta Cremonesi4, and Alessandro Lascialfari1
1University of Pavia, Pavia, Italy, 2Champalimaud Center for the Unknown, Lisbon, Portugal, 3Instituto Superior Técnico, Lisbon, Portugal, 4European Institute of Oncology IRCCS, Milan, Italy

This study tested the hypothesis that some MRI-based radiomic features could lose their texture descriptive power below a volume threshold, compromising the robustness of prediction models. The ability of features to discriminate different textures as a function of the tumor volume was investigated on T2-weighted images of a customized pelvic phantom. The images were acquired on three scanners and considered three different textures, from a finer to a coarser one. The texture discriminative ability was shown to depend on tumor volume, with most features losing this property with a VOI smaller than 1 cm3 at 1.5 T.

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