Abstract #2840

Fitting kinetic rate constants in metabolite-specific bSSFP hyperpolarized [1-13C]pyruvate MRI

Sule Sahin^1,2, Shuyu Tang³, Manushka Vaidya², and Peder E.Z. Larson²

¹Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, Berkeley, CA, United States, ²Radiology, University of California, San Francisco, San Francisco, CA, United States, ³HeartVista, Inc., Los Altos, CA, United States

An alternate to AUC ratio, fitting pyruvate to lactate rate constants (kPL) can be a powerful tool for quantification of hyperpolarized [1-¹³C]pyruvate studies. In this work, a model was developed to fit kPL values to a novel acquisition method where lactate was acquired with a stack-of-spiral bSSFP sequence. The model was utilized to fit kPL on three sets of in vivo data: healthy rat kidneys, mouse prostate tumors and human kidney tumors. It was shown that the fit kPL values matched those fit using an established GRE fitting method for complimentary GRE-acquired data sets.

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