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Abstract #2840

Fitting kinetic rate constants in metabolite-specific bSSFP hyperpolarized [1-13C]pyruvate MRI

Sule Sahin1,2, Shuyu Tang3, Manushka Vaidya2, and Peder E.Z. Larson2
1Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, Berkeley, CA, United States, 2Radiology, University of California, San Francisco, San Francisco, CA, United States, 3HeartVista, Inc., Los Altos, CA, United States

An alternate to AUC ratio, fitting pyruvate to lactate rate constants (kPL) can be a powerful tool for quantification of hyperpolarized [1-13C]pyruvate studies. In this work, a model was developed to fit kPL values to a novel acquisition method where lactate was acquired with a stack-of-spiral bSSFP sequence. The model was utilized to fit kPL on three sets of in vivo data: healthy rat kidneys, mouse prostate tumors and human kidney tumors. It was shown that the fit kPL values matched those fit using an established GRE fitting method for complimentary GRE-acquired data sets.

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