Abstract #2843

Time Dependency of the Continuous-Time Random-Walk Diffusion Model at Long Diffusion Times in the Human Brain

Guangyu Dan^1,2, Yuxin Zhang^3,4, Zheng Zhong^1,2, Kaibao Sun¹, Muge Karaman^1,2, Diego Hernando^3,4, and Xiaohong Joe Zhou^1,2,5

¹Center for MR Research, University of Illinois at Chicago, Chicago, IL, United States, ²Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ³Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Radiology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United States, ⁵Departments of Radiology and Neurosurgery, University of Illinois at Chicago, Chicago, IL, United States

It has been increasingly reported that the diffusion-weighted MRI signal depends on not only the b-value but also the diffusion time. Investigations of diffusion model parameters on diffusion time can provide information on interaction between water molecules and their environment, thus helping reveal tissue microstructures. In this study, we focused on two special cases of a continuous-time random-walk (CTRW) diffusion model; and investigated the diffusion-time dependency of the CTRW parameters in the human brain. Our results showed significant dependency of the CTRW parameters on diffusion times in the range of 100-1000 ms.

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