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Abstract #2845

A direct link between the DKI model and the sub-diffusion process

Qianqian Yang1 and Viktor Vegh2,3
1Queensland University of Technology, Brisbane, Australia, 2The University of Queensland, Brisbane, Australia, 3Centre for Innovation in Biomedical Imaging Technology, Brisbane, Australia

Diffusion kurtosis imaging (DKI) is an important tool in tissue microstructure studies. The DKI formula for diffusion-weighted MRI signal decay arises through a high order expansion, and the kurtosis has been shown to be sensitive to changes in tissue microstructure. Interestingly, the kurtosis formula describes deviation away from mono-exponential signal decay, like that previously described for anomalous diffusion. Here, we make a link between anomalous sub-diffusion in tissue and diffusion kurtosis. This direct link enables the apparent diffusivity and kurtosis to be computed easily from the sub-diffusion model parameters, leading to superior white-grey matter contrast compared with standard DKI parameters.

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