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Abstract #2846

Elaborating and Testing Activity MRI [aMRI] Diffusion Modeling

Brendan Moloney1, Xin Li1, Eric M. Baker1, and Charles S. Springer1
1Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States

Activity MRI [aMRI] simulates diffusion-weighted data with three metabolic and cytometric tissue properties: kio (s-1), the mean steady-state cellular water efflux rate constant [measuring cellular metabolic activity], r, the cell density (cells/μL), and V (pL), the average cell volume. We explore the behavior of the aMRI model, and compare its results with pertinent experimental data. The model is well-behaved, and matches experimental data with parameter values in near absolute agreement with independent literature measurements.

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