Abstract #2847

The effect of inversion time on a two-compartment SMT and NODDI: an in vivo study

Dominika Ciupek¹, Maryam Afzali², Fabian Bogusz¹, Marco Pizzolato^3,4, Derek K. Jones², and Tomasz Pięciak^1,5

¹AGH University of Science and Technology, Kraków, Poland, ²Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ³Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, ⁴Signal Processing Lab (LTS5), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁵LPI, ETSI Telecomunicación, Universidad de Valladolid, Valladolid, Spain

We investigate the effect of the inversion time on the spherical mean technique (SMT) and neurite orientation dispersion and density imaging (NODDI) metrics based on the multi-parametric diffusion MR data. Our findings indicate the orientation dispersion index and mean orientation of Watson distribution remains unchanged for a wide range of TI, while volume fractions and diffusivities show significant changes leading to characteristic "up-and-down" behavior concerning the TI used to fit the model.

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