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Abstract #2847

The effect of inversion time on a two-compartment SMT and NODDI: an in vivo study

Dominika Ciupek1, Maryam Afzali2, Fabian Bogusz1, Marco Pizzolato3,4, Derek K. Jones2, and Tomasz Pięciak1,5
1AGH University of Science and Technology, Kraków, Poland, 2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 3Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark, 4Signal Processing Lab (LTS5), École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland, 5LPI, ETSI Telecomunicación, Universidad de Valladolid, Valladolid, Spain

We investigate the effect of the inversion time on the spherical mean technique (SMT) and neurite orientation dispersion and density imaging (NODDI) metrics based on the multi-parametric diffusion MR data. Our findings indicate the orientation dispersion index and mean orientation of Watson distribution remains unchanged for a wide range of TI, while volume fractions and diffusivities show significant changes leading to characteristic "up-and-down" behavior concerning the TI used to fit the model.

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