Meeting Banner
Abstract #2848

Implications of a constant tissue-trace constraint on the two-compartment free water model

Jordan A. Chad1,2, Ofer Pasternak3, and J. Jean Chen1,2
1Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, 3Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

It has been found that when the single-shell two-compartment free water fit is initialized with a constant trace of the tissue tensor, the final results maintain this constant tissue-trace. It is therefore important to understand the implications of the constant tissue-trace constraint in order to interpret the results of single-shell free water studies. Here we demonstrate that this constraint results in allotting all variation in isotropic diffusivity to the free water compartment while the tissue tensor is unaffected by isotropic variations. It is further shown that the isotropic compartment is more linearly aligned with quadratic variations in diffusivity.

This abstract and the presentation materials are available to members only; a login is required.

Join Here