Building a brain template of fiber orientation distribution (FOD) with Diffusion MRI is crucial for population study and disease research on white matter. The population template and “Fixel” based analysis pipeline is increasingly being used for group-wise statistics. The template generated based solely on symmetric diffeomorphic registration of FOD depicts the group-consistent major fiber bundles; however, spatial specificity is far from optimal in regions near cortical gray matter. In this work, we explore the possibility to leverage the complementary information from T1, T2 and Diffusion MRI and build an unbiased human brain FOD template with multimodal registration method.
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