Abstract #2850

Mechanism and quantitative assessment of saturation transfer for water-based detection of the aliphatic protons in carbohydrate polymers

Yang Zhou¹, Peter van Zijl^2,3, Jiadi Xu^2,3, and Nirbhay N. Yadav^2,3

¹Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Shenzhen, China, ²The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

A three-pool relayed NOE (rNOE) model and its theoretical solution is formulated to describe the rNOE-based signal in CEST experiments and the analytical solution for rNOE transfer presented. We show that experimental data for glycogen solutions in D₂O and H₂O could be analyzed successfully using this analytical theory, which was further validated using numerical simulations with the Bloch equations. The study increases the understanding of the aliphatic components of Z-spectra of sugar polymers as well as of other macromolecules such as proteins and lipids.

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