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Abstract #2850

Mechanism and quantitative assessment of saturation transfer for water-based detection of the aliphatic protons in carbohydrate polymers

Yang Zhou1, Peter van Zijl2,3, Jiadi Xu2,3, and Nirbhay N. Yadav2,3
1Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Shenzhen, China, 2The Russell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

A three-pool relayed NOE (rNOE) model and its theoretical solution is formulated to describe the rNOE-based signal in CEST experiments and the analytical solution for rNOE transfer presented. We show that experimental data for glycogen solutions in D2O and H2O could be analyzed successfully using this analytical theory, which was further validated using numerical simulations with the Bloch equations. The study increases the understanding of the aliphatic components of Z-spectra of sugar polymers as well as of other macromolecules such as proteins and lipids.

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