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Abstract #2857

Established a rat model of discogenic low back pain for evaluating the paravertebral muscle functional magnetic resonance changes

Luo Bao fa1, Huang Yi long1, Yang Kai wen1, Nie Li sha2, and He Bo1
1The First Affiliated Hospital of Kunming Medical University, kunming, China, 2GE Healthcare, MR Research China, Beijing, Beijing, China

In this study, a discogenic low back pain (DLBP) model was established by puncture of rat intervertebral disc under the guidance of X-ray, and functional magnetic resonance imaging (fMRI) was performed on paravertebral muscles of DLBP rats to explore the feasibility of the DLBP model and the changes of T2 value and R2*value of paravertebral muscles in the early stage of DLBP. The conclusion is that it is feasible to construct DLBP rat model by X-ray guided puncture of intervertebral disc, and the T2 value changes earlier than R2*in the early stage of DLBP.

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